Moxifloxacin hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

第四代合成氟喹诺酮类广谱抗菌剂，对革兰氏阳性菌和革兰氏阴性菌均具有活性。

A fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria; inhibits DNA gyrase and topoisomerase IV.Bacterial Infection Approved(In Vitro):The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.(In Vivo):Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic.

The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected by L. monocytogenes EGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation.

Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic. Animal Model:144 white male Wistar rats (18-22 weeks; 300-400 g) infected Stenotrophomonas maltophilia Dosage:12 mg/kg Administration:Intravenous injection; once per day, twice per day, three times per day; for 7 days Result:Showed considerably less bacterial overgrowth in the spleens and lungs and without being toxic.

BAY 12-8039

GPCR/G Protein

Antibacterial

TopoII|TopoIV

Infection

Bacterial Infection

186826-86-8

437.8923

C21H25ClFN3O4

>98% (HPLC)

DMSO: ≥ 31 mg/mL

COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years